Turning Brain Insights into Therapeutic Innovations
Translational Neurometrics is a new contract research organization (CRO) focused on preclinical neuroscience. By blending advanced in vivo neurotechnology, distilled knowledge of the neural basis of brain functions, and a history of effective collaborations, we unravel the actions of potential therapies in the brain through targeted translational studies.
Our approach
Neuronal Recordings in vivo
The electrical activity of neurons in the intact brain opens a window into the intricate brain workings behind motivation, emotion, and cognition. We translate these insights
into innovative therapies.
Neural decoding
AI-approaches are integral to our data analysis, enabling discovery of treatment effects and their precise quantification. We ensure rigorous data analysis through a blind study design and data shuffling, maximizing our potential for discoveries.
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Combining in vivo recordings
with genetic methods
Whether mouse genetic, pharmacogenetic or optogenetic models, our pioneering experience in integrating these approaches with sophisticated in vivo neural recordings
makes us one of the best equipped to tackle challenges in this new frontier of restoring brain function.
Neurometrics
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Brain function and disorders
Metabolic and endocrine signals of reduced energy substrates in blood or adipose
tissue induce hunger. In obesity, low efficacy of this bodily feedback to the brain
leads to increased appetite regardless of the status of energy stores.
Brain region
The hypothalamus senses various bodily signals and translates them into
motivational drives, including hunger, to ensure the survival of the organism.
Damage, genetic defects or manipulations in the arcuate nucleus of the
hypothalamus or its output neural pathways lead to hyperphagia and obesity in
humans and rodents.
Neurometric
The hypothalamus contains appetite-stimulating and appetite-reducing neurons.
These neurons change their activity in response to the adipose tissue
hormone leptin, glucagon-like peptide 1 (GLP-1) or its receptor agonists. GLP-1 agonists
reduce body weight to a large extent by changing the firing of appetite-regulating neurons.
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Methodology
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Neuronal recordings from the arcuate and dorsomedial nuclei in mice in a free-feeding model
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Systemic administration
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Classification of recorded neurons based on their responses to food, analysis
of firing rate in appetite-stimulating and appetite-reducing neurons
(Extended assessment)
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Neuronal recordings in the lateral hypothalamus, which is responsible for the
control of feeding bouts duration
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Systemic administration
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Analysis of neuronal activity within feeding bouts
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Appetite
Aggression
​Episodic memory
Fear
Sleep
Mood
Cognitive control
Cognitive Maps
Expertise
Our company is backed by decades of experience in systems neuroscience research. Using sophisticated techniques for monitoring, manipulating, and analyzing neural activity and behavior, we have made significant contributions to understanding brain functions ranging from memory to feeding. Collaborations across institutions and countries have catalyzed new research directions, enriched teams' capabilities, and advanced the field. We foster this collaborative spirit in our new alliances.
Vision
We live in an era when life-changing cures for devastating diseases are emerging faster than ever before. A great quantity-to-quality transformation of the amount of research into people’s benefit. Neuroscience has been a leading research area in recent decades, and we have learned a great deal about how brain cells create perceptions, emotions, motivations, cognition, and movement.
Responsibility
​At Translational Neurometrics, we uphold the highest ethical and scientific standards in our preclinical research. We ensure high welfare standards for our subjects, adhere to rigorous methodologies for reliable results, and prioritize data privacy and security to protect all collected data. These practices ensure the highest quality of research and safeguard the interests of all our clients.
About Us
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